Research progress of cell transplantation in the treatment of osteochondral lesions of the talus
10.3760/cma.j.cn501098-20230218-00089
- VernacularTitle:细胞移植技术治疗距骨骨软骨损伤的研究进展
- Author:
Hao WANG
1
;
Feng QU
;
Shenglong DING
;
Songmin SUN
;
Mingzhu ZHANG
Author Information
1. 首都医科大学附属北京同仁医院足踝外科中心，北京 100730
- Keywords:
Talus;
Ankle injuries;
Chondrocytes;
Cell transplantation;
Mesenchymal stem cell transplantation
- From:
Chinese Journal of Trauma
2023;39(7):665-672
- CountryChina
- Language:Chinese
-
Abstract:
Osteochondral lesions of the talus (OLT) frequently manifest following ankle joint trauma, causing ankle pain, swelling and impaired mobility, thereby significantly impeding daily activities of the patients. Presently, clinical treatment approaches encompass both conservative management and surgical intervention. Conservative management endeavors to alleviate symptoms, while patients experiencing persistent symptoms resort to surgical intervention. Commonly employed surgical treatments encompass bone marrow stimulation, autologous osteochondral transplantation, and allogeneic osteochondral transplantation. Bone marrow stimulation is employed as a therapeutic approach for the management of smaller OLT, demonstrating favorable short-term effectiveness; however, the long-term prognosis remains uncertain. Autologous osteochondral transplantation is a viable option for larger OLT lesions, albeit it carries the potential of complications at the donor site. Conversely, allogenic osteochondral transplantation exhibits a diminished success rate. In recent times, the utilization of cell transplantation techniques has garnered escalating interest in the treatment of OLT due to their capacity to regenerate cartilage resembling hyaline and their diverse range of cellular origins. The authors reviewed the progress of cell transplantation in the treatment of OLT, providing a reference for the clinical treatment.
