A case of carbamazepine induced acute interstitial nephritis.
- Author:
Bong Kwan RYU
1
;
Ji Yong JEONG
;
Bum Yun KIM
;
Young Uk SEO
;
Jung In KIM
;
Jong Hoon CHUNG
;
Hyun Lee KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Chosun University, Kwangju, Korea. hyunkim@chosun.ac.kr
- Publication Type:Case Report
- Keywords:
Nephritis;
Interstitial;
Renal failure;
Acute;
Carbamazepine
- MeSH:
Biopsy;
Blood Platelets;
Blood Pressure;
Carbamazepine*;
Eosinophils;
Epilepsy;
Exanthema;
Humans;
Intracranial Hemorrhages;
Kidney;
Lower Extremity;
Lymphocytes;
Male;
Middle Aged;
Necrosis;
Nephritis;
Nephritis, Interstitial*;
Renal Insufficiency;
Sensation
- From:Korean Journal of Medicine
2004;66(4):408-413
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Acute interstitial nephritis often caused by drugs and infection. Interstitial nephritis by drugs is a kind of idiosyncratic reaction and is caused independently of dosage. This disease developed within several days or weeks after taking medicine but improved if discontinue medication. Adrenocortical hormone may shorten the period of disease if renal dysfunction continued. Acute interstitial nephritis by carbamazepine that is used for epilepsy cure is rarely reported. A 49-year-old male was admitted to our hospital because of skin rash and decreased urine volume which developed 10 days ago. Patient was diagnosed intracranial hemorrhage 6 months ago and was taking carbamazepine because of tingling sensation to lower extremity before 2 months. At admission, blood pressure 120/80 mmHg, hemoglobin 12.6 g/dL, WBC 232,000/mm3, eosinophil count 2,790/mm3, platelet 166,000/mm3. Urine findings indicated protein 1+, blood 2+ and eosinophil was observed in microscopic examination. Abdominal sonography showed increase of both kidney size, shade of renal cortex and Resistance index (RI). Renal biopsy showed inflammatory cell consisted of lymphocyte, eosinophil in parenchyme was seen with tubular necrosis partially. Renal function was improved after carbamazepine withdrawal and adrenocortical hormone medication.
