Basic researches over spinal cord injury: problems and countermeasures
10.3760/cma.j.cn501098-20230131-00052
- VernacularTitle:脊髓损伤基础研究存在的问题及改进建议
- Author:
Shujie ZHAO
1
;
Jian CHEN
;
Guoyong YIN
Author Information
1. 南京医科大学第一附属医院骨科，南京 210029
- Keywords:
Spinal cord injuries;
Models, animal;
Clinical research
- From:
Chinese Journal of Trauma
2023;39(5):408-414
- CountryChina
- Language:Chinese
-
Abstract:
Spinal cord injury leads to extremely high mortality and disability rates and its treatment has always been a global challenge. The survival of patients with spinal cord injury is partially lengthened with the development of medical treatments, but the clinical outcome is still not satisfactory. Some important progress has been made in the basic researches over spinal cord injury, such as analysis of repair mechanism of spinal cord injury and development of cellular therapies and biological scaffolds of spinal cord injury in China. However, some basic researches show insufficient understanding of the microenvironment and animal model of spinal cord injury and lack support from clinical problems, leading to too simplistic or contradictory conclusions. There is an urgent need to reexamine the research methods and carry out basic and clinical translational researches. Therefore, the authors discuss the key problems and difficulties in basic researches over spinal cord injury and propose improvement suggestions, aiming to provide a reference for conducting basic researches correctly and accelerating clinical innovational transformation.
