Research progress in influencing factors and pathogenesis of dementia after traumatic brain injury

VernacularTitle:创伤性脑损伤后痴呆的影响因素及致病机制研究进展
Author: Xianzheng SANG ¹ ; Chengqing WANG ; Lijun HOU
Author Information

1. 海军军医大学第二附属医院神经外科，上海　200003
Keywords: Brain injuries, traumatic; Dementia; Chronic traumatic encephalopathy; Alzheimer disease
From: Chinese Journal of Trauma 2023;39(2):185-192
CountryChina
Language:Chinese
Abstract: Traumatic brain injury (TBI) has been recognized as a risk factor for developing dementia. Currently, around 69 million people worldwide suffer from TBI each year, while the overall incidence of TBI among Chinese residents is on a rapid rise. Such a large population of TBI patients may lead to a future surge in the number of dementia patients, bringing heavy burdens on families and societies. However, it seems to be suggested by numerous studies that not all TBI patients are associated with an increased risk of dementia. Dementia can result in disability as well as interfere with caregivers ′ normal lives. Therefore, it will be significant to clarify the relationship between TBI and dementia as well as explain the process of onset and development of post-TBI dementia. In this study, the authors summarize post-TBI dementia from aspects of influencing factors and pathogenic mechanisms, so as to provide relevant references for related studies, therapy, and prophylaxis of post-TBI dementia.