Research progress in characteristics of intestinal flora and intestinal flora-targeted therapeutic methods in patients with spinal cord injury
10.3760/cma.j.cn501098-20220812-00552
- VernacularTitle:脊髓损伤患者肠道菌群特征及以肠道菌群为靶点的治疗方法研究进展
- Author:
Shuwen LIU
1
;
Xiuyun WANG
;
Haixia CHEN
;
Yinjie CUI
Author Information
1. 天津中医药大学实验针灸学研究中心，天津 301617
- Keywords:
Spinal cord injuries;
Gastrointestinal microbiome;
Targeted therapy
- From:
Chinese Journal of Trauma
2023;39(1):76-82
- CountryChina
- Language:Chinese
-
Abstract:
Patients with spinal cord injury is associated with seriously affected gastrointestinal function and imbalance of intestinal flora, leading to increased inflammation of spinal cord nerves. With the proposal of the theory of gut microbiota-gut-brain axis in recent years, the regulatory role of gut microbiota in the central nervous system and gastrointestinal system has gradually attracted attention. Although a considerable number of studies have focused on the effects of intestinal flora characteristics on spinal cord nerve function repair in patients with spinal cord injury from different perspectives, there are numerous research models for treating spinal cord injury with intestinal flora as intervention targets and remains a lack of unified and effective clinical treatment methods. In this paper, the authors review the research progress in characteristics of intestinal microflora and intestinal microflora-targeted therapeutic methods in patients with spinal cord injury, hoping to provide a reference for the clinical treatment and basic research of spinal cord injury.
