Expert consensus for the clinical application of autologous bone marrow enrichment technique for bone repair (version 2023)
- VernacularTitle:自体骨髓富集骨修复技术临床应用专家共识（2023版）
- Author:
Junchao XING
1
;
Long BI
;
Li CHEN
;
Shiwu DONG
;
Liangbin GAO
;
Tianyong HOU
;
Zhiyong HOU
;
Wei HUANG
;
Huiyong JIN
;
Yan LI
;
Zhonghai LI
;
Peng LIU
;
Ximing LIU
;
Fei LUO
;
Feng MA
;
Jie SHEN
;
Jinlin SONG
;
Peifu TANG
;
Xinbao WU
;
Baoshan XU
;
Jianzhong XU
;
Yongqing XU
;
Bin YAN
;
Peng YANG
;
Qing YE
;
Guoyong YIN
;
Tengbo YU
;
Jiancheng ZENG
;
Changqing ZHANG
;
Yingze ZHANG
;
Zehua ZHANG
;
Feng ZHAO
;
Yue ZHOU
;
Yun ZHU
;
Jun ZOU
Author Information
- Keywords: Bone marrow; Bone transplantation; Osteogenesis; Bone substitutes
- From: Chinese Journal of Trauma 2023;39(1):10-22
- CountryChina
- Language:Chinese
- Abstract: Bone defects caused by different causes such as trauma, severe bone infection and other factors are common in clinic and difficult to treat. Usually, bone substitutes are required for repair. Current bone grafting materials used clinically include autologous bones, allogeneic bones, xenografts, and synthetic materials, etc. Other than autologous bones, the major hurdles of rest bone grafts have various degrees of poor biological activity and lack of active ingredients to provide osteogenic impetus. Bone marrow contains various components such as stem cells and bioactive factors, which are contributive to osteogenesis. In response, the technique of bone marrow enrichment, based on the efficient utilization of components within bone marrow, has been risen, aiming to extract osteogenic cells and factors from bone marrow of patients and incorporate them into 3D scaffolds for fabricating bone grafts with high osteoinductivity. However, the scientific guidance and application specification are lacked with regard to the clinical scope, approach, safety and effectiveness. In this context, under the organization of Chinese Orthopedic Association, the Expert consensus for the clinical application of autologous bone marrow enrichment technique for bone repair ( version 2023) is formulated based on the evidence-based medicine. The consensus covers the topics of the characteristics, range of application, safety and application notes of the technique of autologous bone marrow enrichment and proposes corresponding recommendations, hoping to provide better guidance for clinical practice of the technique.
