Incidence and risk factors of renal injury in human immunodeficiency virus infection/acquired immunodeficiency syndrome patients with poor immune reconstitution
10.3760/cma.j.cn311365-20230104-00005
- VernacularTitle:免疫重建不良的人类免疫缺陷病毒感染/艾滋病患者肾损伤的发生率及其危险因素
- Author:
Danyan YU
1
;
Xumin YING
;
Huili LI
;
Zhangqing ZHOU
;
Xiaofeng ZHENG
;
Dingyan YAN
;
Zongxing YANG
;
Wenhui ZHANG
;
Guoxiang ZHENG
;
Zhongdong ZHANG
;
Jianhua YU
Author Information
1. 杭州市中医院肾内科，杭州 310007
- Keywords:
Acquired immunodeficiency syndrome;
Poor immune reconstitution;
Kidney injury;
Risk factors
- From:
Chinese Journal of Infectious Diseases
2023;41(8):502-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the incidence and risk factors of renal injury in human immunodeficiency virus (HIV) infection/acquired immunodeficiency syndrome (AIDS) patients with poor immune reconstitution.Methods:The HIV infection/AIDS patients with poor immune reconstitution who were visited Second Department of Infection of Hangzhou Xixi Hospital from January to December 2021 were enrolled. The clinical data and laboratory examinations of the patients were collected, and the relevant risk factors were analyzed by logistic regression.Results:Among 303 HIV infection/AIDS patients with poor immune reconstitution, 59(19.5%) patients had renal injury. Logistic regression analysis showed that hypertension (odds ratio ( OR)=0.200, 95% confidence interval (95% CI) 0.065 to 0.618, P=0.005), taking tenofovir ( OR=0.275, 95% CI 0.130 to 0.580, P=0.001), hypoproteinemia ( OR=1.045, 95% CI 1.006 to 1.086, P=0.022), and low CD4 + T lymphocytes level ( OR=1.009, 95% CI 1.003 to 1.014, P=0.001) were risk factors for renal injury. Conclusions:The incidence of renal injury in HIV infection/AIDS patients with poor immune reconstitution is high. Hypertension, taking tenofovir, hypoproteinemia, and low CD4 + T lymphocytes level are risk factors for renal injury in patients.
