Epidemiological features of pathogens of acute respiratory tract infection in children in Guangzhou area from 2018 to 2021
10.3760/cma.j.cn311365-20220523-00196
- VernacularTitle:2018年至2021年广州地区儿童急性呼吸道感染病原体的流行特征
- Author:
Jiahui XIE
1
;
Lu KUANG
;
Jiayu ZHONG
;
Yingying ZHANG
;
Yi CHEN
;
Xiaomin LIU
;
Wanli LIANG
;
Fuying CHEN
;
Minzhang TAN
;
Bing ZHU
Author Information
1. 广州市妇女儿童医疗中心中心实验室，广州 510120
- Keywords:
Acute respiratory tract infection;
Pathogens;
Epidemiological features;
Children
- From:
Chinese Journal of Infectious Diseases
2023;41(2):137-143
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiology of pathogens of acute respiratory tract infection (ARTI) in children in Guangzhou area.Methods:A total of 13 610 hospitalized children with ARTI in Guangzhou Women and Children′s Medical Center from January 2018 to December 2021 were enrolled. Throat swab specimens were collected, and fluorescent quantitative polymerase chain reaction (PCR) was performed to detect 11 respiratory pathogens, including respiratory syncytial virus (RSV), adenovirus (ADV), parainfluenza virus (PIV), human rhinovirus (HRV), human bocavirus (HBoV), human metapneumovirus (HMPV), enterovirus (EV), influenza A virus (IFA), influenza B virus (IFB), Mycoplasma pneumoniae (MP) and Chlamydia pneumoniae (CP). Grouping according to age (< one year group, one to < three years group, three to < six years group, six to 14 years group) and season. Chi-square test was used for statistical analysis. Results:At least one pathogen was detected in 6 331 cases among 13 610 patients, and the overall positive rate was 46.52%. The detection rates from high to low were as follows: RSV (13.75%(1 872/13 610)), ADV (4.82%(656/13 610)), PIV (4.82%(656/13 610)), MP (4.54%(618/13 610)), HRV (3.39%(462/13 610)), HBoV (2.64%(359/13 610)), HMPV (2.59%(352/13 610)), EV (1.76%(239/13 610)), IFA (1.29%(176/13 610)), IFB (0.90%(122/13 610)) and CP (0.30%(41/13 610)). The positive rate of viral detection showed significant differences among different age groups ( χ2=49.91, P<0.001), and the highest positive rate was in the age group of one to
