Pathological diagnosis and molecular alternations of pulmonary mucinous adenocarcinoma
10.3760/cma.j.cn101721-20230530-000198
- VernacularTitle:肺黏液腺癌的病理诊断及分子机制
- Author:
Jiting DI
1
;
Yan XIONG
Author Information
1. 北京大学第一医院病理科，北京 100034
- Keywords:
Mucinous adenocarcinoma;
Non-mucinous adenocarcinoma;
Histology;
Immunophenotype;
Molecular Genetics
- From:
Clinical Medicine of China
2023;39(4):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Primary pulmonary mucinous adenocarcinoma is a rare subtype of lung adenocarcinoma. It differs from non-mucinous adenocarcinoma in etiology, pathogenesis, clinical, imaging, histological, immunophenotypic and genotypic features, prognosis and treatment. pulmonary mucinous adenocarcinoma mainly originates from bronchial basal cells and mucous cells. Tumor cells show a goblet and/or columnar cell morphology with abundant intracytoplasmic mucin and basally oriented nuclei, with a typical lepidic-predominant growth, the commonest molecular alterations are KRAS mutations.
