Advances in the study of the pathogenesis of squamous cell carcinoma
10.3760/cma.j.cn101721-20220925-000437
- VernacularTitle:鳞状细胞癌发病机制研究进展
- Author:
Yuren DUAN
1
;
Jiaxin WANG
;
Xiaobing WANG
;
Hua HAN
Author Information
1. 山西医科大学第一医院整形美容烧伤外科，太原 030001
- Keywords:
Carcinoma;
Squamous Cell;
Genetics
- From:
Clinical Medicine of China
2023;39(1):69-74
- CountryChina
- Language:Chinese
-
Abstract:
Squamous cell carcinoma, which originates from squamous epithelium or tissue that undergoes squamous epithelial metaplasia, is one of the most common pathological types of solid human carcinoma. Although squamous cell carcinoma can occur in different anatomical locations, its pathogenesis has commonalities and distinctive features. Genetic mutations and abnormal expression of squamous differentiation markers, epigenetic modifications regulating target gene expression, and tumor microenvironment inducing immune escape of cancer cells are all involved in the development of squamous cell carcinoma. At present, great progress has been made in the research on the pathogenesis of squamous cell carcinoma. This article, combined with relevant research in recent years, reviews the pathogenesis of squamous cell carcinoma in terms of genome changes, epigenetic changes, non coding RNA regulation, tumor microenvironment changes and risk factor induction, so as to provide reference for the prevention and treatment of squamous cell carcinoma.
