Analysis of multiline therapy for small cell lung cancer transformed from lung adenocarcinoma and review of the literature
10.3760/cma.j.cn101721-20221016-000473
- VernacularTitle:肺腺癌转化小细胞癌的多线治疗分析及文献复习
- Author:
Yunpeng LI
1
;
Tengfei ZHOU
;
Haiying YU
;
Yang ZHANG
;
Jing QIAN
;
Hongtao MAO
;
Hao ZHOU
;
Jiangming LI
Author Information
1. 解放军92493部队医院普外胸外肿瘤科，葫芦岛 125000
- Keywords:
Transforming small cell lung cancer;
Lung adenocarcinoma;
Immunotherapy
- From:
Clinical Medicine of China
2023;39(1):32-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effect of multi line therapy for lung adenocarcinoma transformed into small cell lung cancer (SCLC), and review and discuss the related literature.Methods:Combined with the clinical examples of lung adenocarcinoma transformed SCLC after treatment with anti epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs), the diagnostic process and multi line treatment plan of transformed SCLC were analyzed, and the therapeutic effect was evaluated by imaging. At the same time, it was reviewed and discussed in combination with relevant literature.Results:Serological tumor markers were significant for the diagnosis of transformed SCLC after EGFR-TKI treatment of lung adenocarcinoma, and pathology was still the gold standard for its diagnosis. The multiline therapy of SCLC has certain effect on transformed small cell lung cancer.Conclusion:The overall prognosis of lung adenocarcinoma transformed into SCLC after EGFR TKIs treatment is poor, so it is necessary to diagnose and treat it as early as possible, evaluate the effect of imaging in time, and make treatment adjustment quickly.
