Prevalence and influencing factors of sleep disorder in HIV/AIDS patients before antiviral therapy
10.3760/cma.j.cn431274-20220710-00641
- VernacularTitle:HIV/AIDS患者抗病毒治疗前睡眠障碍现况及影响因素
- Author:
Lizhi FENG
1
;
Bo LIU
;
Han ZHAO
;
Xinhua LIU
;
Danna ZHENG
;
Peishan DU
;
Haolan HE
Author Information
1. 广州医科大学附属市八医院感染病中心，广州 510060
- Keywords:
HIV infections;
Acquired immunodeficiency syndrome;
Sleep disorders
- From:
Journal of Chinese Physician
2023;25(7):1016-1019
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To understand the incidence of sleep disorder in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients before antiviral therapy, and to explore its risk factors.Methods:200 newly treated HIV/AIDS patients who visited the Eighth Affiliated City Hospital of Guangzhou Medical University from January to June 2016 were randomly selected. According to the Pittsburgh Sleep Quality Index (PSQI), they were divided into a good sleep group and a Sleep disorder group; The influencing factors of sleep disorder in HIV/AIDS patients were analyzed by univariate analysis and multivariate logistic regression.Results:The incidence of Sleep disorder in 200 HIV/AIDS patients before antiviral therapy was 22.5%(45/200); CD4 + T cell count was (414.13±202.16)/μl; 29%(58/200) of patients had CD4 + T cell counts<200/μl. There were significant differences in CD4 + T cell count and the proportion of patients with syphilis infection, comorbidity anxiety and comorbidity depression between the good sleep group and the Sleep disorder group (all P<0.05). Multivariate logistic regression analysis showed that syphilis infection ( OR=4.606; 95% CI: 1.973-10.752; P<0.001), comorbidity anxiety ( OR=2.496; 95% CI: 1.086-5.737; P=0.031) and comorbidity depression ( OR=2.087; 95% CI: 0.915-4.760; P=0.040) were risk factors for sleep disorder in HIV/AIDS patients before antiviral treatment. Conclusions:The incidence of Sleep disorder in HIV/AIDS patients before antiviral therapy in Guangzhou is high, especially in patients with syphilis infection, comorbidity anxiety and comorbidity depression. The sleep disorder of HIV/AIDS patients should be assessed and detected early, and multiple interventions should be taken to improve sleep quality.
