A preliminary study on the relationship between neural development and gut microbiota in preterm infants
10.3760/cma.j.cn431274-20220822-00839
- VernacularTitle:早产儿神经发育与肠道菌群关系的初步研究
- Author:
Ye MA
1
;
Lihong TAN
;
Ruiwen HUANG
;
Zhenyu LIAO
;
Guinan LI
;
Xiaoming PENG
;
Jun QIU
Author Information
1. 湖南省儿童医院感染科，长沙 410007
- Keywords:
Infant, premature;
Intestinal flora;
Neurodevelopment
- From:
Journal of Chinese Physician
2023;25(7):998-1002,1007
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the neural development of preterm infants and gut microbiota.Methods:66 premature infants who were hospitalized in the Neonatology Department of Hunan Children′s Hospital from September 2018 to September 2019 were included in the study. Their fecal samples and clinical data from the first admission were collected. According to the neurodevelopment, the patients were divided into normal neurodevelopment group and neurodysplasia group. The bacterial DNA of fecal samples was extracted by 16S rDNA high-throughput sequencing technology and bioinformatics analysis was conducted to compare the composition and diversity of gut microbiota between the two groups.Results:(1) The Shannon index of gut microbiota in normal neurodevelopmental group and neurodysplastic group was 0.89(0.41, 1.51) and 1.01(0.47, 1.31), respectively. There was no significant difference in diversity index between the two groups ( P>0.05). (2) Bifidobacterium, veronica and negativites in the gut microbiota of the normal neurodevelopmental group were significantly higher (all P<0.05), and streptococcus in the gut microbiota of the dysplastic group were significantly higher ( P<0.05). The gut microbiota of the two groups were mainly enterococcus and escherichia shigella. Conclusions:At the genus level, enterococcus and escherichia are the dominant flora of early gut microbiota in preterm infants. Gut microbiota is related to the neural development of preterm infants. The increased abundance of streptococcus, and the decreased abundance of bifidobacterium, veronicus, and negativites may be risk factors for neurodysplasia of preterm infants. The diversity of gut microbiota in early preterm infants may not be significantly related to neural development.
