Research status of CHEK2 gene and breast cancer

VernacularTitle:CHEK2基因与乳腺癌相关性研究现状
Author: Huan YU ¹ ; Jinzhu MA
Author Information

1. 内蒙古医科大学附属医院甲乳外科，呼和浩特　010000
Keywords: Breast neoplasms; CHEK2 gene; Mutation; Susceptibility gene
From: Journal of Chinese Physician 2023;25(6):942-945
CountryChina
Language:Chinese
Abstract: At present, breast cancer is one of the main causes of death for women in the world. In recent years, the incidence rate of breast cancer in China has also been rising. Existing studies have shown that the most fully studied gene for breast cancer susceptibility is breast cancer susceptibility gene 1/2 (BRCA1/2), and other genes related to the increased risk of breast cancer have also been confirmed, including cell-cycle-checkpoint kinase gene 2 (CHEK2), which is a tumor suppressor gene encoding serine/Threonine kinase CHEK2. The gene is involved in DNA repair, cell cycle regulation, apoptosis and other DNA damage response pathways. This article reviews the research status of CHEK2 gene and its important role in the prevention, diagnosis and treatment of breast cancer.