Research progress of vitamin D, monocyte chemoattractant protein-1 and Hashimoto's thyroiditis

VernacularTitle:维生素D、单核细胞趋化蛋白-1与桥本甲状腺炎关系的研究进展
Author: Lihua SUN ¹ ; Shulong SHI ; Lin SUN
Author Information

1. 济宁医学院临床医学院，济宁　272067
Keywords: Vitamin D; Monocyte chemokine protein-1; Hashimoto thyroiditis
From: Journal of Chinese Physician 2023;25(6):937-941
CountryChina
Language:Chinese
Abstract: Hashimoto thyroiditis (HT) is one of the most common autoimmune thyroid disease, and its pathogenesis has not been fully clarified at present. Most people believe that it is induced by mental stress, overwork, infection, stress, environmental pollution, unreasonable diet structure (such as high iodine diet) and other factors on the basis of genetic defects and genetic susceptibility. Vitamin D is a steroid hormone that maintains the balance of calcium and phosphorus metabolism in the body, regulating bone and mineral salt metabolism. Monocyte chemoattractant protein-1 (MCP-1) is a member of the chemokine CC family. It binds to chemokine receptor (CCR) and participates in immune inflammatory response. In recent years, more and more studies have found that vitamin D and MCP-1 are involved in the occurrence and development of many immune diseases, including Hashimoto thyroiditis. This article reviews the new research progress of the role of vitamin D and MCP-1 in Hashimoto thyroiditis.