Research progress of tripartite motif-containing protein 28 in tumors
10.3760/cma.j.cn431274-20220723-00718
- VernacularTitle:三结构域蛋白28在肿瘤中的研究进展
- Author:
Kun YAN
1
;
Jianqiang WANG
;
Yanfeng JIANG
;
Pingan WANG
;
Dong XUE
Author Information
1. 滨州医学院临床医学院，烟台 264003
- Keywords:
Tripartite motif-containing protein 28;
Epithelial-mesenchymal transition;
E3 ubiquitin ligases;
Neoplasms
- From:
Journal of Chinese Physician
2023;25(4):630-633
- CountryChina
- Language:Chinese
-
Abstract:
Tripartite motif-containing protein 28 is a kind of macromolecular protein with E3 ubiquitin ligase, which belongs to an important member of the TRIM protein family. As a new molecular biomarker, it has attracted wide attention. TRIM28 is highly expressed in many kinds of malignant tumors, which is closely related to clinicopathological features, and is also involved in biological behaviors such as proliferation, apoptosis, migration and invasion of tumor cells. TRIM28 may be a potential marker and therapeutic target for clinical diagnosis and prognosis of tumors. This study reviews the structure and biological function of TRIM28, its relationship with malignant tumors and the molecular mechanism of signal transduction pathway.
