Research progress on the involvement of poly (ADP-ribose) polymerase-1-dependent cell death in ischemia-reperfusion injury
10.3760/cma.j.cn431274-20221114-01170
- VernacularTitle:PARP-1依赖性细胞死亡在缺血再灌注损伤中的研究进展
- Author:
Luyao WANG
1
;
Yixun TANG
;
Jingshi LIU
;
Jitong LIU
Author Information
1. 湖南省人民医院（湖南师范大学附属一医院）麻醉科，长沙 410000
- Keywords:
Reperfusion injury;
Parthanatos;
Poly (ADP-ribose) polymerase-1;
Apoptosis inducing factor
- From:
Journal of Chinese Physician
2023;25(4):626-629
- CountryChina
- Language:Chinese
-
Abstract:
Ischemia reperfusion injury (IRI) of organs is a major challenge for clinicians, but the mechanism is still not elucidated, and the clinical treatment effect is still unsatisfactory. PARP-1-dependent cell death (parthanatos) is a non-apototic programmed cell death pathway involved in the development of the occurrence of IRI of organs. At the same time, parthanatos is also a multi-step pathway. There are many molecules in the parthanatos cascade that can be exploited to create therapeutic interventions for IRI, including PARP1, apoptosis inducing factor (AIF), and macrophage migration inhibitory factor (MIF). These critical molecules are involved in DNA damage, energy depletion and homeostasis imbalance. Therefore, these molecular signals in the parthanatos cascade represent promising therapeutic targets for the treatment of IRI. In the following, we will elaborate on the mechanisms and molecular characteristics of the parthanatos pathway and the relation between parthanatos pathway and IRI of vital organs. It aims to explore the posibility of IRI mechanism research and clinical treatment and to provide new ideas for clinicians and researchers.
