The role of circRNAs in renal cell carcinoma
10.3760/cma.j.cn431274-20220708-00635
- VernacularTitle:环状RNA在肾细胞癌诊断和治疗作用中的研究进展
- Author:
Wei CAI
1
;
Yanting SHEN
Author Information
1. 上海市奉贤区医疗急救中心急救科，上海 200233
- Keywords:
RNA, circular;
Carcinoma, renal cell
- From:
Journal of Chinese Physician
2023;25(3):472-476
- CountryChina
- Language:Chinese
-
Abstract:
Renal cell carcinoma is a malignant tumor originating from renal tubular epithelial cells. Its pathogenesis is complicated, with no typical early clinical symptoms. Most patients are already in the advanced stage at the time of diagnosis and have a high mortality rate. The development mechanism and treatment strategy of renal cell carcinoma are the current research focus. In recent years, non-coding RNA has been proved to play a crucial role in regulating tumor progression. Among them, circular RNA plays a unique role in tumor development due to its nonlinear structure. The dysregulation of circular RNA is closely related to the progression of a series of diseases including metabolic diseases and cancer. Similarly, circular RNA plays a key role in the progression, treatment, and prognosis prediction of renal cell carcinoma. This article briefly reviews role of circular RNA in renal cell carcinoma, hoping to bring new research directions for the diagnosis and treatment of renal cell carcinoma.
