Research progress of p53 protein in the development mechanism of triple negative breast cancer

VernacularTitle:p53蛋白在三阴性乳腺癌发展机制中的研究进展
Author: Haoying SUN ¹ ; Jinzhu MA
Author Information

1. 内蒙古医科大学附属医院甲乳外科，呼和浩特　010050
Keywords: Triple negative breast neoplasms; Tumor suppressor protein p53
From: Journal of Chinese Physician 2023;25(2):310-313
CountryChina
Language:Chinese
Abstract: Tumor suppressor gene p53 plays an important role in regulating cell cycle, controlling apoptosis and repairing damaged DNA. Mutation of this gene is closely related to the occurrence, development and drug resistance of various tumors. The mutant p53 protein is closely related to the growth and metastasis of triple negative breast cancer (TNBC) with higher malignancy and higher risk of metastasis. This paper expounds the mechanism of p53 protein participating in the occurrence, development and metastasis of TNBC, introduces the effect of interfering with mouse dual-microbody gene 2 (MDM2), activated T cell nuclear factor 1 (NFAT1) and other proteins on p53, as well as small molecular targeted drugs closely related to p53 protein, and provides a new direction and theoretical basis for targeted treatment of TNBC.