The relationship of RDW-SD, NLR and FIB with the prognosis of multiple myeloma patients and their predictive value
10.3760/cma.j.cn431274-20220124-00062
- VernacularTitle:RDW-SD、NLR及FIB与多发性骨髓瘤患者预后的关系及预测价值
- Author:
Qian HUANG
1
;
Chunyan YANG
;
Haiyan WANG
;
Yu HUANG
;
Panpan CHENG
;
Hao ZHANG
Author Information
1. 济宁医学院附属医院血液科，济宁 272029
- Keywords:
Multiple myeloma;
Red blood cell distribution width;
Neutrophils;
Lymphocytes;
Fibrinogen
- From:
Journal of Chinese Physician
2023;25(1):76-80
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the relationship between the standard deviation of red blood cell distribution width (RDW-SD), neutrophil/lymphocyte value (NLR), fibrinogen (FIB) and the prognosis of multiple myeloma (MM) patients and their predictive value.Methods:In this study, a retrospective study method was used to select 120 patients with MM who were initially diagnosed in the department of hematology of the Affiliated Hospital of Jining Medical College from January 2017 to October 2019. The follow-up time was 24 months, including 62 patients who survived (survival group) and 58 patients who died (death group). The RDW-SD, NLR and FIB values of the two groups were compared, and the value of the three indicators in predicting the follow-up outcome of MM patients was analyzed using the receiver operating characteristic (ROC) curve. Logistic regression model was used to analyze the related factors affecting the prognosis of MM patients.Results:Among 120 newly treated MM patients, the RDW-SD, NLR and FIB of the survival group were significantly lower than those of the death group (all P<0.05); The sensitivity, specificity and area under ROC curve (AUC) of RDW-SD+ NLR+ FIB in predicting adverse outcomes of MM patients were 88.96%, 84.50% and 0.919 respectively. Logistic multivariate regression analysis showed that ≥60 years old, International Staging System (ISS) Ⅲ, β2-microglobulin (β2-MG)≥3 500 ng/ml, increased RDW-SD, NLR, and FIB will increase the risk of poor prognosis in MM patients (all P<0.05). Conclusions:The RDW-SD, NLR and FIB have a close relationship with the poor prognosis of newly treated MM patients, and the combined application has certain value in predicting the prognosis of patients.
