Research progress of hypoxia signal pathway in renal cell carcinoma

VernacularTitle:缺氧信号通路在肾癌中的研究进展
Author: Jinglei ZANG ¹ ; Kangxiao GUO ; Sisheng XU ; Tao CHEN ; Xiaomei WEI
Author Information

1. 长沙卫生职业学院药学院，长沙　410000
Keywords: Kidney neoplasms; Hypoxia-inducible factor 1; Hypoxia
From: Journal of Chinese Physician 2022;24(12):1905-1908
CountryChina
Language:Chinese
Abstract: Hypoxia is an important basic feature of the solid tumor microenvironment. With the deepening of the research on the pathogenesis of renal cell carcinoma (RCC), the expression and function of hypoxia and hypoxia inducible factor (HIF) in RCC have attracted more and more attention. The hypoxia signal pathway has become a research hotspot of tumor and other diseases in recent years. This article reviews the current understanding of hypoxia signal pathway, its correlation with the occurrence and development of RCC, and the application prospect of HIF inhibitors, in order to guide the precise treatment of clinical RCC.