Working memory deficits in Parkinson's disease mouse model
10.3867/j.issn.1000-3002.2023.07.089
- Author:
Tingting ZHAO
1
,
2
;
Huating GU
;
Miao ZHAO
;
Tianzhi CHEN
;
Yingjie AN
;
Xian ZHANG
;
Jincan HOU
;
Peng CAO
;
Linghui ZENG
;
Chengyu LI
Author Information
1. Institute of Neuroscience,State Key Laboratory of Neu-roscience,Chinese Academy of Sciences,CAS Center for Excellence in Brain Science and Intelligence Technology,Shanghai Center for Brain Science and Brain-Inspired Tech-nology,Shanghai 200031,China
2. Hangzhou City University,Hangzhou 310015,China
- Keywords:
Parkinson's disease;
neural circuit;
synaptic transmission;
working memory;
optogenetics
- From:
Chinese Journal of Pharmacology and Toxicology
2023;37(7):517-518
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE Parkinson's disease(PD)is a progressive neurodegenerative disease clinically char-acterized by dyskinesia,tremor,rigidity,abnormal gait,whereas 90%of patients with PD suffer from defects of the sense of smell before the appearance of the motor dysfunctions.However,the mechanism of olfactory disor-der is still not clear.METHODS We utilized olfaction based delayed paired association task in head-fixed mice.We focused on functional role of neural circuit using opto-genetic techniques.In addition,we viewed the synaptic transmission by slice physiological recording and count-ed the cell number of targeted circuits.RESULTS AND CONCLUSION In our experiments,olfactory working memory impairments were found in the PD mice,and the working memory impairment appeared before motor dys-functions.Furthermore,we also investigated the functional role of neural circuit for olfactory working memory in PD mice.Meanwhile,the excitatory post synaptic currents were decreased as a result of presynaptic release proba-bility suppression in PD mice.However cell loss wasn't found in working memory related circuit recently.These will provide a new idea of clinic diagnosis for PD.
