Flavonoid compounds improve hippocampal neuro-genesis and cognitive dysfunction in mice
10.3867/j.issn.1000-3002.2023.07.074
- Author:
Guixiang WANG
1
;
Qingqing ZHANG
;
Jiahui LIANG
;
Manli ZHANG
;
Xiaoying GOU
;
Binbin DAI
;
Yongxiang LIU
;
Jingyu YANG
;
Yuting LI
Author Information
1. Wuya College of Innovation,Shenyang Pharmaceutical University,Shenyang 110016,China
- Keywords:
flavonoid compounds;
NSC-specific promoter transgenic mice;
hippocampus,NSC lineage progression
- From:
Chinese Journal of Pharmacology and Toxicology
2023;37(7):511-511
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the improve-ment functions of flavonoid compounds on temozolomide(TMZ)-,aging-or AD model-induced dysregulation of hip-pocampal NSC lineage progression,retardancy of den-dritic spine maturation in new-born neurons,as well as impairment of hippocampal-related learning and memory.METHODS We applied 30-week-old neural stem cell(NSC)specific promoter Nestin-GFP and NestinCreERT2:Rosa26-LSL-tdTomato transgenic mice and 16-week-old AD model 5XFAD transgenic mice,together with hippo-campal microinjection(ih),endogenous fluorescence trac-ing and immunofluorescent staining.RESULTS Both fla-vonoid compound A and its functional derivative flavo-noid compound B dose-dependently improved TMZ-,aging-or AD-induced defects of hippocampal NSC lin-eage progression and the maturation of dendritic spines of newborn neurons,thereby improving hippocampus related learning and memory.CONCLUSION This paper provides a new idea and treatment strategy for the devel-opment of new flavonoids that can promote neurogene-sis for neurodegenerative diseases and aging.
