Vascular endothelial cell dysfunction and Alzheimer's disease
10.3867/j.issn.1000-3002.2023.07.035
- Author:
Xinhai JIANG
1
;
Lan ZHANG
Author Information
1. Department of Pharmacy,Xuanwu Hospital of Capital Medical University,National Clinical Research Center for Geriatric Diseases,Beijing Engineering Research Center for Nervous System Drugs,Beijing Institute for Brain Disor-ders,Key Laboratory for Neurodegenerative Diseases of Ministry of Education,Beijing 100053,China
- Keywords:
Alzheimer's disease;
blood-brain barrier;
peripheral arterial vascular endothelial cell
- From:
Chinese Journal of Pharmacology and Toxicology
2023;37(7):494-495
- CountryChina
- Language:Chinese
-
Abstract:
Alzheimer's disease(AD)is a neurode-generative disease with complex pathological mecha-nism characterized by accumulation of amyloid plaques and neurofibrillary tangles in the brain.Increasing evi-dence suggests that vascular dysfunction due to endothe-lial cell injury may have a pathogenic role in the occur-rence and development of AD.Malfunction of the blood-brain barrier caused by endothelial cell dysfunction is associated with the accumulation of several neurotoxic molecules within brain parenchyma,a reduction in cerebral blood flow,amyloid-β transfer and hypoxia,especially at the early stages of the disease.At the same time,it can-not be ignored that the peripheral arterial vascular endo-thelial cell dysfunction also seems to be closely related to the risk and the severity of symptoms of AD.Some mole-cules are thought to be messengers connecting the central and peripheral endothelial cells.Peripheral and central vascular endothelial cells communicate with each other and influence the progression of AD through some common mechanisms.In this review,we provide an ap-praisal of the endothelial cell dysfunction in cerebral and systemic vasculature,and give the evidence that vascular pathology is inextricably linked to disease onset and pro-gression of AD.
