Progress in magnetic resonance imaging study of anhedonia and suicidal behavior in depression

VernacularTitle:抑郁症快感缺失和自杀行为的磁共振成像研究进展
Author: Xiaoqin WANG ¹ ; Rui YAN ; Yi XIA ; Zhijian YAO
Author Information

1. 南京医科大学附属脑科医院心境障碍科，南京　210029
Keywords: Depression; Anhedonia; Suicide; Magnetic resonance imaging; Structure; Function
From: Chinese Journal of Behavioral Medicine and Brain Science 2023;32(5):461-466
CountryChina
Language:Chinese
Abstract: Many studies have found a correlation between suicidal behavior (SB) and anhedonia, the main symptom of depression, in terms of both psychological and neurophysiological findings. The purpose of this review is to find the relationship between the two neuroimaging mechanisms, and to provide help for the future study of how the brain imaging changes can promote the mechanism of SB in depression patients with anhedonia symptoms. This review also emphasizes the necessity of intervention for the symptoms of anhedonia when preventing depression from committing suicide. The latest research results were reviewed about anhedonia in depression and magnetic resonance imaging of SB.The results showed that the default network, insula, lateral orbitofrontal gyrus, anterior cingulate gyrus, ventral striatum gyrus, ventral lateral and dorsolateral prefrontal gyrus, thalamus and habenula nucleus were dysfunction in depression with state anhedonia symptoms, affecting SB in terms of mood, execution, reward and aversion processing, especially the low lethal SB.