Iron deposition and Parkinson disease
10.3760/cma.j.cn371468-20220902-00514
- VernacularTitle:铁沉积与帕金森病
- Author:
Jiaxi SONG
1
;
Wei JIN
;
Peiyuan LYU
Author Information
1. 河北省人民医院神经内科，河北省脑网络与认知障碍疾病重点实验室，石家庄 050051
- Keywords:
Iron deposition;
Central nervous system disease;
Parkinson disease
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(3):272-277
- CountryChina
- Language:Chinese
-
Abstract:
Iron is an essential metal element for human body. It is involved in many important biological metabolic processes. Iron metabolism in the central nervous system has a strict regulatory mechanism. Iron deposition occurs when the homeostasis of iron metabolism is disrupted, leading to an increase in neuronal iron uptake and a decrease in iron discharge. Aging cells develop specific iron deposition, and excessive iron produce reactive oxygen species, which can damage DNA. Highly reactive aldehydes result in irreversible modification of proteins. Stored proteins were stimulated to release iron, which in turn produces more reactive oxygen species, ultimately leading to iron-mediated cell death and neurological dysfunction. The widely used methods for assessing iron deposition include susceptibility weighted imaging and quantitative susceptibility mapping. Abnormally elevated brain iron deposition has been observed in a variety of central nervous system diseases, especially in Parkinson disease. Iron deposition plays an important role in early diagnosis, differential diagnosis, disease evaluation and monitoring and therapeutic effect evaluation of Parkinson disease. This article reviews the research progress of iron deposition in Parkinson disease.
