Comparation of resting brain regional homogeneity between patients with major depressive disorder and their healthy siblings
10.3760/cma.j.cn371468-20220711-00393
- VernacularTitle:重性抑郁障碍患者与其健康兄弟姐妹静息态脑局部一致性比较
- Author:
Feng LI
1
;
Zhifang ZHANG
;
Baohua ZHANG
;
Fang DONG
;
Lei ZHAO
;
Zhenzhu CHEN
;
Tian LI
;
Yimeng WANG
;
Qijing BO
;
Chuanyue WANG
Author Information
1. 首都医科大学附属北京安定医院，国家精神心理疾病临床医学研究中心，精神疾病诊断与治疗北京市重点实验室，北京 100088
- Keywords:
Major depressive disorder;
Healthy sibling;
Resting state;
Functional magnetic resonance imaging;
Regional homogeneity
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2023;32(3):225-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore differences of resting brain regional homogeneity (ReHo) between patients with major depressive disorder (MDD) and their siblings.Methods:From January to December 2013, the resting-state functional magnetic resonance imaging (fMRI) data of 87 patients with MDD and 21 healthy siblings were collected.DPABI v5.1 software was used to preprocess the resting-state fMRI data, and ReHo maps of each subject was obtained. A two-sample t-test was used to compare differences between the patients with MDD and their siblings in ReHo values throughout the brain. ReHo values within the significant brain regions were extracted out, and used to calculate Spearman correlation with the total score of 17-items Hamilton depression rating scale(HAMD-17) in the patients with MDD and their siblings respectively.The software of SPSS 20.0 was used for statistical analysis. Results:The patients with MDD exhibited lower ReHo values in the precuneus extending to the posterior cingulate cortex (PCu/PCC) compared with their siblings (cluster-size=126 voxel, cluster-level PFDR=0.033; MNI: x=-4, y=-58, z=38, t=4.30). ReHo values of the PCu/PCC in patient with MDD were positively correlated with the severity of depressive symptoms ( r=0.255, P=0.021). Conclusion:Compared with the siblings, local brain activity of the PCu/PCC in the patients with MDD was decreased, and related to the severity of depressive symptoms. It is helpful to further reveal the intrinsic neural mechanism of MDD.
