Research progress of sepsis-associated acute kidney injury based on Gut-Kidney axis

VernacularTitle:基于肠-肾轴的脓毒症相关性急性肾损伤的研究进展
Author: Li ZHANG ¹ ; Yi WANG ; Xiangyou YU
Author Information

1. 新疆医科大学护理学院，乌鲁木齐　830001
Keywords: Sepsis; Sepsis-associated acute kidney injury; Gut microbiota; Gut-kidney axis
From: Chinese Critical Care Medicine 2023;35(3):329-333
CountryChina
Language:Chinese
Abstract: Sepsis-associated acute kidney injury (SA-AKI), as a common renal dysfunction in sepsis, has become one of the major diseases threatening human health with increasing morbidity and mortality. Based on the theory of "gut-kidney axis", the intestine and kidney have a two-way synergistic relationship in sepsis. Intestinal flora imbalance, endogenous metabolite imbalance, and impaired endothelial barrier integrity are involved in renal injury, and the increase of renal inflammatory mediators interferes with the composition of intestinal microorganisms. Therefore, understanding the intestinal-renal crosstalk mechanism of SA-AKI will help to provide a potential basis for new treatment strategies for SA-AKI.