Research progress on mechanism of biotrauma caused by ventilation-induced lung injury
10.3760/cma.j.cn121430-20220801-00701
- VernacularTitle:机械通气相关性肺损伤生物伤发生机制的研究进展
- Author:
Siyu LIAN
1
;
Leilei ZHOU
;
Wenqing JIANG
;
Xianming ZHANG
Author Information
1. 贵州医科大学附属医院呼吸与危重症医学科，贵阳 550004
- Keywords:
Ventilation-induced lung injury;
Biotrauma;
Inflammation response;
Oxidative stress;
Complement activation;
Blood-gas barrier
- From:
Chinese Critical Care Medicine
2023;35(2):217-220
- CountryChina
- Language:Chinese
-
Abstract:
Mechanical ventilation is an advanced life support treatment for patients with acute respiratory failure. While stabilizing respiratory function, it also acts as an injury factor to exacerbate or lead to lung injury, that is, ventilation-induced lung injury (VILI). There may be a more subtle form of damage to VILI known as "biotrauma". However, the mechanism of biotrauma in VILI is still unclear. This article intends to review the mechanism of biotrauma of VILI from the aspects of inflammatory response, oxidative stress and complement activation, in order to provide a new strategy for clinical prevention and treatment of biotrauma caused by VILI.
