Research progress of transcription activating factor 3 in regulating the alveolar macrophages in acute respiratory distress syndrome
10.3760/cma.j.cn121430-20220531-00516
- VernacularTitle:转录活化因子3调控肺泡巨噬细胞在急性呼吸窘迫综合征中作用的研究进展
- Author:
Chengjun HUANG
1
;
Xiaoyi SHU
;
Yu XU
;
Jinrui DONG
;
Youxia LI
;
Siqi LI
;
Hongman WANG
Author Information
1. 遵义医科大学第五附属（珠海）医院呼吸与危重症医学科，广东珠海 519100
- Keywords:
Transcription activating factor 3;
Acute respiratory distress syndrome;
Alveolar macrophage;
Autophagy;
Endoplasmic reticulum stress
- From:
Chinese Critical Care Medicine
2023;35(1):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Acute respiratory distress syndrome (ARDS) refers to acute diffuse lung injury caused by a variety of intrapulmonary and/or extrapulmonary factors such as infection and trauma. Uncontrolled inflammatory response is the main pathological feature. Different functional states of alveolar macrophages have different effects on inflammatory response. Transcription activating factor 3 (ATF3) is a fast response gene in the early stage of stress. In recent years, it has been found that ATF3 plays an important role in regulating the inflammatory response of ARDS by regulating the function of macrophages. This paper reviews the regulatory effects of ATF3 on alveolar macrophage polarization, autophagy and endoplasmic reticulum stress and its effects on the inflammatory process of ARDS, aiming to provide a new research direction for the prevention and treatment of ARDS.
