Antihypertensive Effects of Nilvadipine(Nivadil(R)) in Patients with Essential Hypertension.
10.4070/kcj.1993.23.6.820
- Author:
Eun Seok JEON
;
Chong Hun PARK
- Publication Type:Original Article
- Keywords:
Nilvadipine;
Essential hypertension
- MeSH:
Antihypertensive Agents;
Calcium Channel Blockers;
Calcium Channels;
Dizziness;
Fatigue;
Flushing;
Half-Life;
Headache;
Heart Rate;
Humans;
Hypertension*
- From:Korean Circulation Journal
1993;23(6):820-825
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Form the 1970's calcium channel blockers have been used as one of the most effective drugs for antihypertensive therapy. Nilvadipine(Nivadil(R)) is a new vessel-selective calcium channel blocker with a markedly high oral bioaviliability and a long elimination half-life time. To evaluate the efficacy and side effects of nilvadipine, daily monotherapy was done in 22 patients with essential hypertension. METHOD: After more than 2 weeks of previous drug wash-out periods, Nilvadipine 8-12mg was administered daily in 2 or 3 divided dosage for 8 weeks in patients with mild to severe essential hypertension. The sitting blood pressure(BP) and heart rate were measured before and 2, 4, 8 weeks after medication. RESULT: Systolic and diastolic BP were significantly reduced at 2 weeks after medication and no further significant BP reduction were noted throughout the remainer of the trial(4 to 8 weeks). Normotension(diastolic BP < or =90mmHg) was achieved in 14 cases(67%) after 8 weeks therapy and in 7 cases(33%) BP reduced effectively. The side effect noted were headache and facial flushing in 2 cases and in one of them the medication were discontinued. And fatigue, dizziness were complaint in 1 case respectively. There were no significant laboratory changes before and after nilvadipine therapy. CONCLUSION: It can be concluded that nilvadipine(Nivadil(R)) monotherapy is effective in many patients with essential hypertension and a clinical study of combined therapy with other antihypertensive agents in larger numbers of patients will be needed.
