The Clinical Effects of Perindopril(Acertil(R)) on Hypertensive Patients.
10.4070/kcj.1993.23.6.826
- Author:
Myung Ho JEONG
;
Jung Pyung SUH
;
Myung Kon LEE
;
Jong Soo PARK
;
Young Keun AHN
;
Joo Hyung PARK
;
Eun Ah JEONG
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
;
Young Geol PARK
;
Young Joon KANG
- Publication Type:Original Article
- Keywords:
Perindopril;
Antihypertensive agent;
Left ventricular hypertrophy
- MeSH:
Blood Pressure;
Cough;
Echocardiography;
Electrocardiography;
Female;
Flushing;
Follow-Up Studies;
Heart Rate;
Humans;
Hypertension;
Hypertrophy, Left Ventricular;
Male;
Peptidyl-Dipeptidase A;
Perindopril;
Quality of Life;
Tachycardia, Sinus
- From:Korean Circulation Journal
1993;23(6):826-836
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Perindopril. a new second-generation angiotensin converting enzyme inhibitor developed by Servier Research, was administered in essential hypertensive patients in order to observe the clinical effects. METHOD: The changes of blood pressure, heart rate, quality of life, clinical laboratory examinations, side effects, electrocardiogram and echocardiographic left ventricular mass were evaluated before and after 4-12mg of perindopril 12 weeks' administration in 25 essential hypertensive patients(mild 10, moderate 8, severe 5, very severe 2 : male 7, female 18 ; mean age 53.1+/-8.9 years). RESULT: 1) After treatment with perindopril alone, blood pressures were lowered markedly in 17(68%), moderately in 5(20%) and mildly in 2(8%) cases. The average of blood pressures of 25 subjects were systolic 173.1+/-22.8mmHg and diastolic 105.9+/-9.5mmHg before treatment, which were lowered to 125.2+/-14.9mmHg and 83.2+/-9.0mmHg respectively after 12 weeks(p<0.0001). 2) Quality of Life improved markedly in 11(44%) and slightly in 9(36%) cases after perindopril administration. 3) On electrocardiographic follow-up study, three out of five left ventricular hypertrophy with strain, seven out of 13 left ventricular hypertrophy, two out of three ST segment and T wave change and two sinus tachycardia were improved. Echocardiographic left ventricular mass was reduced significantly form 249.4+/-72.7g to 202.9 56.3g after 12 weeks perindopril treatment(p<0.0001). 4) Side effects were 5 cases of dry cough and 3 facial flushing. 5) Final Assessment of perindopril effect including hypotensive effect, quality of life, left ventricular mass regression and side effect showed very useful in 16(64%) and useful in 6(24%) out of 25 subjects. CONCLUSION: Perindopril may be an effective initial single antihypertensive agent for the treatment of varying degree of hypertension, especially with left ventricular hypertrophy.
