Research progress of effect of neutrophil elastase and its inhibitors in sepsis
10.3760/cma.j.cn121430-20220419-00389
- VernacularTitle:中性粒细胞弹性蛋白酶及其抑制剂在脓毒症中作用的研究进展
- Author:
Lu YAO
1
;
Jiqian XU
;
Xiaobo YANG
;
You SHANG
Author Information
1. 华中科技大学同济医学院附属协和医院重症医学科，湖北武汉 430022
- Keywords:
Sepsis;
Neutrophil elastase;
Neutrophil elastase inhibitor
- From:
Chinese Critical Care Medicine
2022;34(11):1209-1212
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a clinical syndrome of life-threatening organ dysfunction caused by infection. When an infection occurs, as the first line of defense of the body's immune system, neutrophils are first recruited to the site of infection to capture and kill pathogens by releasing neutrophil elastase (NE). However, a large amount of NE release will injury the surrounding normal tissues and induce organ dysfunction or failure. NE inhibitors can inhibit NE activity and reduce inflammatory response, which may be a promising drug for the treatment of sepsis. Currently, a variety of NE inhibitors have been developed and reported, but there is no systematic overview of their characteristics, and the role and underlying mechanisms of NE and related inhibitors in sepsis have not been thoroughly discussed. This article will make a review in this regard, in order to elucidate the effect of NE and its inhibitors in sepsis.
