Research progress on the skeletal muscle mitochondrial alterations and the treatment in cancer cachexia

VernacularTitle:肿瘤恶病质的肌肉线粒体改变及治疗研究进展
Author: Yifu HU ¹ ; Yao LI ; Jingyong XU
Author Information

1. 北京医院普通外科　肝胆胰外科　100730
Keywords: Neoplasm; Cachexia; Skeletal muscle; Mitochondria
From: Chinese Journal of Clinical Nutrition 2023;31(2):117-122
CountryChina
Language:Chinese
Abstract: Cancer cachexia is a multifactorial syndrome characterized by the continuous loss of skeletal muscle. The pathogenic mechanism of cancer cachexia remains unknown, and the effectiveness of routine nutritional therapy is limited. The mitochondrial disorder is demonstrated to play an important role in the mechanism of tumor-induced skeletal muscle atrophy, including alterations to the mitochondrial ultrastructure, biogenesis, dynamics, mitophagy, and functions. Interventions targeting mitochondrial alterations provide a potential solution to cancer cachexia and represent a new focus in this research field.