Research progress of soluble growth stimulating gene 2 protein in cardiovascular disease
10.3760/cma.j.cn341190-20210530-00626
- VernacularTitle:可溶性生长刺激表达基因2蛋白与心血管疾病的研究进展
- Author:
Zhen LIU
1
;
Jingwu SUN
;
Huipu XU
;
Yanli CHENG
;
Jingsen LI
;
Jian WANG
Author Information
1. 滨州医学院附属医院心内科，滨州 256603
- Keywords:
Receptors, interleukin-1;
Heart failure;
Coronary disease;
Hypertension;
Atrial fibrillation;
Cardiomyopathies;
Aortic diseases;
Hypertension,pulmonary
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(8):1276-1280
- CountryChina
- Language:Chinese
-
Abstract:
Growth stimulating gene 2 (ST2) protein is a member of the interleukin-1 receptor family. It is mainly divided into a soluble secreted form sST2 and a transmembrane form ST2L. sST2 is a decoy receptor that competitively binds to interleukin-33 to block the interleukin-33/ST2L signaling pathway, worsening myocardial hypertrophy, fibrosis, and ventricular dysfunction. Measuring sST2 is of important value for diagnosis and/or prognosis evaluation of cardiovascular diseases. This paper mainly reviews the research progress in the relationship between cardiovascular diseases such as heart failure, coronary heart disease, hypertension, atrial fibrillation, myocarditis, cardiomyopathy, acute aortic dissection, and pulmonary hypertension, and sST2.
