Research progress on sex hormone-binding globulin involved in the occurrence and development of diabetes mellitus
10.3760/cma.j.cn341190-20221020-00817
- VernacularTitle:性激素结合球蛋白参与糖尿病发生发展的研究进展
- Author:
Yuhang BAO
1
;
Hong SU
;
Rendong ZHENG
Author Information
1. 南京中医药大学附属中西医结合医院 南京中医药大学第三临床学院内分泌科，南京 210028
- Keywords:
Diabetes mellitus;
Insulin resistance;
Sex hormone-binding globulin;
Genotype;
Fatty liver;
DNA methylation;
Hepatocyte nuclear factor 4;
Glucose transport p
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(7):1112-1115
- CountryChina
- Language:Chinese
-
Abstract:
Sex hormone-binding globulin (SHBG) is significantly associated with abnormal glucose metabolism. Low SHBG level is a risk factor for insulin resistance and the occurence of diabetes mellitus. SHBG is negatively correlated with the risk of type 2 diabetes mellitus and plays an important role in regulating insulin resistance while predicting its development. The genotype of SHBG has been found to be closely related to the occurrence of diabetes mellitus. Fatty liver and DNA methylation are also important factors mediating the relationship between SHBG and type 2 diabetes mellitus. The change in SHBG level may be related to insulin resistance by influencing hepatocyte nuclear factor 4a and regulating glucose transporter.
