Evaluation methods and application progress of drug cytotoxicity in vitro
10.3760/cma.j.cn341190-20210331-00406
- VernacularTitle:药物体外细胞毒性评价方法及其应用进展
- Author:
Liangbing WEI
1
;
Li SHAN
;
Jiarong GAO
;
Yutong WANG
Author Information
1. 安徽中医药大学第一附属医院药学部 国家中医药管理局中药制剂三级实验室,合肥 230031
- Keywords:
Drug toxicity;
Cells;
Pharmacogenomic testing;
Evaluation studies;
Review
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(6):956-960
- CountryChina
- Language:Chinese
-
Abstract:
Drugs have both therapeutic and toxic side effects. How to quickly determine the toxicity of the test substance is very important for drug development. In vitro cytotoxicity testing compensates for the shortcomings of using animal models for toxicity evaluation. Its role in toxicity evaluation is increasingly important. The development of computer technology and in-depth research in proteomics, genomics, and metabolomics provide a method for in vitro cytotoxicity evaluation towards a faster and more accurate direction. This paper reviews the commonly used cells, evaluation indicators, and detection techniques for in vitro cytotoxicity evaluation, in order to provide some reference for related research.
