Risk factors of cardiovascular and cerebrovascular diseases in young patients with hyperhomocysteinemia
10.3760/cma.j.cn341190-20220913-00712
- VernacularTitle:青年高同型半胱氨酸血症患者心脑血管疾病相关危险因素分析
- Author:
Mudan FENG
1
;
Yu XIA
;
Ming SUN
;
Yuzhen ZHANG
;
Xia CHENG
;
Yuanbin WU
;
Yuhong WANG
Author Information
1. 解放军总院第七医学中心急诊科，北京 100700
- Keywords:
Homocysteine;
Risk factors;
Cardiovascular diseases;
Cerebrovascular disorders;
Young adult
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(6):881-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the risk factors of cardiovascular and cerebrovascular diseases in young patients with hyperhomocysteinemia.Methods:A total of 260 patients younger than 45 years old who received treatment at the Department of Emergency, Seventh Medical Center, Chinese PLA General Hospital from January 2018 to January 2019 were included in this study. Among these patients, 126 patients with serum homocysteine levels ≥ 15.0 μmol/L were included in the hyperhomocysteinemia group, and 134 patients with serum homocysteine levels < 15.0 μmol/L were included in the control group. Height, body weight, body mass index, blood pressure, homocysteine, fasting blood glucose, blood uric acid, total cholesterol, triacylglycerol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and N-terminal B-type natriuretic peptide were determined in each group. Changes in risk factors of cardiovascular and cerebrovascular diseases were compared between the hyperhomocysteinemia and control groups.Results:There were significant differences in body mass index [(26.42 ± 3.54) kg/m 2vs. (22.14 ± 3.22) kg/m 2, t = 10.21, P = 0.016], blood uric acid [(308.71 ± 78.44) μmol/L vs. (285.05 ± 92.09) μmol/L, t = 2.22, P = 0.027], the incidence of coronary heart disease (73/126 vs. 61/134, χ2 = 4.00, P = 0.045) and the incidence of stroke (19/126 vs. 6/134, χ2 = 8.39, P = 0.004) between the hyperhomocysteinemia and control groups. There were no significant differences in fasting blood glucose, blood lipid level, N-terminal B-type natriuretic peptide, and the incidences of diabetes mellitus and hypertension between the two groups (all P > 0.05). Conclusion:The related risk factors of cardiovascular and cerebrovascular diseases increase in young patients with hyperhomocysteinemia. The incidences of coronary heart disease and stroke are very high, and therefore timely intervention should be carried out.
