Efficacy and safety of percutaneous left atrial appendage occlusion for nonvalvular atrial fibrillation
10.3760/cma.j.cn341190-20221127-00969
- VernacularTitle:左心耳封堵术治疗非瓣膜性心房颤动的有效性和安全性分析
- Author:
Wen ZHANG
1
;
Fei HE
;
Chandong DING
Author Information
1. 安徽医科大学第二附属医院老年心血管内科，合肥 230601
- Keywords:
Atrial fibrillation;
Warfarin;
Rivaroxaban;
Stroke;
Fibrinogen;
Prothrombin time
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(6):835-839
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the efficacy and safety of percutaneous left atrial appendage occlusion in the treatment of nonvalvular atrial fibrillation.Methods:Eighty-eight patients with percutaneous left nonvalvular atrial fibrillation who received treatment in The Second Hospital of Anhui Medical University from January 2019 to January 2021 were included in this study. These patients were divided into three groups according to different anticoagulant methods: group A (percutaneous left atrial appendage occlusion), group B (livaraban), and group C (warfarin). The incidence of stroke, the incidence of bleeding events, the incidence of adverse cardiovascular events, and live and kidney function and coagulation function after 3 months of treatment were compared among the three groups.Results:There were no significant differences in the incidence of stroke and adverse cardiovascular events among the three groups ( P > 0.05). The incidence of bleeding events in groups A, B, and C was 9.3% (3/32), 15.0% (6/40), and 31.2% (5/16), respectively. There was a significant difference in the incidence of bleeding events among the three groups ( χ2 = 8.07, P = 0.001). After 3 months of treatment, there were no significant differences in prothrombin time, fibrinogen, prothrombin time-international normalized ratio, alanine aminotransferase, aspartate transaminase, and creatinine clearance among the three groups (all P > 0.05). Conclusion:Percutaneous left atrial appendage occlusion, warfarin, and rivaroxaban can prevent stroke in patients with nonvalvular atrial fibrillation. Percutaneous left atrial appendage occlusion is safer and more feasible than warfarin and rivaroxaban alone in the treatment of nonvalvular atrial fibrillation.
