Application of leucine-rich alpha-2 glycoprotein 1 in the diagnosis and treatment of digestive system tumors

VernacularTitle:富亮氨酸α-2糖蛋白-1在消化系统肿瘤诊疗中的应用进展
Author: Liyan SUN ¹ ; Lili XU ; Shujun QU
Author Information

1. 烟台市烟台山医院药剂科，烟台　264003
Keywords: LRG1; Tumor; Digestive system; Research progress
From: Chinese Journal of Primary Medicine and Pharmacy 2023;30(5):787-790
CountryChina
Language:Chinese
Abstract: Leucine-rich alpha-2 glycoprotein 1 (LRG1) is a highly conserved member of the family of leucine-rich repeat (LRR) proteins. LRG1 has been reported to be closely related to the occurrence and development of malignant tumors. Recent studies have shown that LRG1 is abnormally expressed in many digestive system tumors, including esophageal cancer, gastric cancer, liver cancer, pancreatic cancer, and colorectal cancer. LRG1 has also been reported to be closely related to tumor cell proliferation, invasion, migration, apoptosis, and poor prognosis. This paper reviews the research progress of LRG1 in many digestive system tumors, providing new ideas for LRG1-based anti-tumor treatment.