Relationship between serum interleukin-6 and interleukin-10 levels and the clinical prognosis of severe acute pancreatitis
10.3760/cma.j.cn341190-20220531-00448
- VernacularTitle:重症胰腺炎患者血清IL-6、IL-10水平与预后的关系研究
- Author:
Fengyan RONG
1
;
Yonglin WANG
;
Shoulei KANG
;
Jinxiu LI
Author Information
1. 聊城市第二人民医院 山东第一医科大学附属聊城二院重症医学科，聊城 252600
- Keywords:
Pancreatitis,acute necrotizing;
Interleukin-6;
Interleukin-10;
Severity of illness index;
Prognosis;
Infection;
Multiple organ failure;
Complication;
Risk fac
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(5):678-682
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between serum interleukin-6 and interleukin-10 levels and clinical prognosis in patients with severe acute pancreatitis.Methods:Ninety-two patients with severe acute pancreatitis who received treatment in The Second People's Hospital of Liaocheng from August 2018 to July 2021 were included in this study. Serum interleukin (IL)-6 and IL-10 levels were detected. The Bedside Index of Severity in Acute Pancreatitis (BISAP) score was evaluated. Clinical interventions were performed. The relationship between serum IL-6 and IL-10 levels and the clinical prognosis of severe acute pancreatitis was investigated.Results:Serum IL-6 level [(103.75 ± 15.53) ng/L] was highest in patients who died. Serum IL-10 level [(97.33 ± 13.06) ng/L] was highest in patients with local complications. The highest number of patients with a prognostic outcome of death [26 (37.14%)] was found in patients with a BISAP score ≥ 3. Serum IL-6 level in patients with severe acute pancreatitis was positively correlated with the BISAP score ( r = 0.62, P < 0.05), and serum IL-6 level and BISAP score were negatively correlated with serum IL-10 level ( r = -0.57, -0.61, both P < 0.05). Conclusion:Increased or decreased serum IL-6 and IL-10 levels in patients with severe acute pancreatitis indicate that the patient's condition tends to worsen, and timely intervention according to serum IL-6 and IL-10 levels can improve the clinical prognosis of severe acute pancreatitis.
