Research progress on the biological activity of pyrrole 1,2-α indole alkaloids
10.3760/cma.j.cn341190-20210703-00772
- VernacularTitle:基于吡咯［1，2-α］吲哚的生物碱的生物活性研究进展
- Author:
Chenglong WANG
1
;
Zhenliang SUN
Author Information
1. 南方医科大学药学院，广州 510515
- Keywords:
Pyrrole [1,2-α] indole;
Heterocycle;
Natural products;
Plant extracts;
Alkaloid;
Biological activity;
Lead compound;
Structure optimization;
Research progress
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(4):635-640
- CountryChina
- Language:Chinese
-
Abstract:
Pyrrole [1,2-α] indole is a novel fused heterocyclic skeleton, which is also the basic structural unit and synthetic intermediate of many natural active products and drugs. Pyrrole [1,2-α] indole heterocyclic derivatives have attracted much attention in organic synthesis and medicinal chemistry because of their extensive and marked biological activities. Plant extracts have always been an important source of active compounds. At present, the alkaloids based on the pyrrole [1,2-α] indole heterocyclic structure discovered and isolated from plant extracts include isatisine, isoborreverine, flinderoles, polyavolensin and yuremamine. This paper reviews the research progress on the biological activity of pyrrole [1,2-α] indole heterocyclic derivatives and has found that pyrrole [1,2-α] indole heterocyclic derivatives have a good development prospect in screening active compounds and developing candidate drugs.
