Effects of nimodipine on cognitive function in patients with Alzheimer's disease
10.3760/cma.j.cn341190-20220423-00344
- VernacularTitle:尼莫地平对阿尔茨海默病患者认知功能的影响观察
- Author:
Weiwei HU
1
;
Wenke WANG
;
Shiqi YANG
Author Information
1. 北京市朝阳区双桥医院神经内科，北京 100000
- Keywords:
Alzheimer disease;
Aged;
Cognitive dysfunction;
Mental status;
Nimodipine;
Cholinesterase inhibitors;
Quality of life;
Treatment outcome
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(4):514-517
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the effects of nimodipine on cognitive function in patients with Alzheimer's disease.Methods:A total of 200 patients with Alzheimer's disease who received treatment in Shuangqiao Hospital from January 2019 to January 2022 were included in this study. They were randomly divided into a control group and an observation group ( n = 100/group). The control group was treated with Donepezil. The observation group was treated with nimodipine and Donepezil. Before and 2 months after treatment, mental status and cognitive function were evaluated in each group. Results:After treatment, total response rate in the observation group was significantly higher than that in the control group [95% (95/100) vs. 81% (81/100), χ2 = 9.58, P < 0.05]. Alzheimer's disease assessment scale cognitive subscale score was significantly lower after treatment compared with before treatment in each group ( P < 0.05). Mini-mental State Examination score was significantly higher after treatment compared with before treatment in each group ( P < 0.05). Alzheimer's disease assessment scale cognitive subscale score in the observation group was significantly lower than that in the control group [(17.38 ± 1.95) points vs. (29.63 ± 3.39) points, t = -3.26, P < 0.05]. Mini-mental State Examination score in the observation group was significantly higher than that in the control group [(23.47 ± 4.59) points vs. (18.68 ± 3.91) points, t = 2.14, P < 0.05]. Conclusion:Nimodipine can improve cognitive function in patients with Alzheimer's disease.
