Effects of butylphthalide combined with hyperbaric oxygen therapy on post-stroke cognitive impairment
10.3760/cma.j.cn341190-20210414-00453
- VernacularTitle:丁苯酞联合高压氧治疗脑卒中后认知障碍的疗效观察
- Author:
Zhi WANG
1
;
Liangbing ZHAO
;
Chao SUN
;
Zhaoyong YU
;
Hao WANG
;
Ying ZHANG
;
Guofang CHEN
Author Information
1. 睢宁县人民医院神经内科，徐州 221200
- Keywords:
Stroke;
Cognitive dysfunction;
Butylphthalide;
Hyperbaric oxygenation;
National institutes of health (U.S.);
Cognitive function;
Activities of daily living
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(4):497-500
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical efficacy of butylphthalide combined with hyperbaric oxygen therapy on post-stroke cognitive impairment in patients with acute ischemic stroke.Methods:A total of 90 patients with post-stroke cognitive impairment who were hospitalized within 72 hours of onset in Suining County People's Hospital from December 2019 to November 2020 were included in this study. They were randomly divided into a control group and an observation group ( n = 45/group). The control group was given conventional treatment and the observation group was given butylphthalide combined with hyperbaric oxygen therapy in addition to conventional treatment. The National Institutes of Health Stroke Scale score, Montreal Cognitive Assessment score, and Activities of Daily Living score were compared between the two groups before and after treatment. Results:Before treatment, there were no significant differences in the National Institutes of Health Stroke Scale score, Montreal Cognitive Assessment score, and Activities of Daily Living score between the two groups (all P > 0.05). At 14 days and 1 month after surgery, the National Institutes of Health Stroke Scale scores in the observation group were (4.02 ± 2.18) points and (3.21 ± 2.03) points, which were significantly lower than (5.21 ± 2.24) points and (4.62 ± 2.68) points in the control group ( t =2.55, 2.81, both P < 0.05). At 1 and 3 months after treatment, the Montreal Cognitive Assessment score in the observation group were (19.79 ± 5.67) points and (23.69 ± 2.67) points, which were significantly higher than (16.88 ± 5.12) points and (19.74 ± 2.29) points in the control group ( t = 2.56, 7.53, both P < 0.05). At 1 and 3 months after treatment, Activities of Daily Living scores in the observation group were (54.85 ± 5.69) points and (74.38 ± 4.98) points, which were significantly higher than (46.78 ± 6.24) points and (63.21 ± 5.24) points in the control group ( t = 6.41, 9.76, both P < 0.05). Conclusion:Butylphthalide combined with hyperbaric oxygen therapy for the treatment of post-stroke cognitive impairment in patients with acute ischemic stroke can alleviate neurologic deficits, and improve cognitive function and the ability of daily life.
