Acute kidney injury caused by rhabdomyolysis which is induced by intestinal infection: a case report and literature review
10.3760/cma.j.cn341190-20211005-01128
- VernacularTitle:肠道感染引发横纹肌溶解致急性肾损伤1例并文献复习
- Author:
Siqi CHEN
1
;
Jiachen CHEN
;
Yunfang ZHANG
;
Yanyan SU
Author Information
1. 南方医科大学附属花都医院 广州市花都区人民医院肾病学科，广州 510800
- Keywords:
Rhabdomyolysis;
Acute kidney injury;
Intestinal infection;
Hemodiafiltration;
Myoglobin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(3):399-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To report a case of acute kidney injury caused by rhabdomyolysis and summarize its etiology, pathogenesis, and treatment strategy.Methods:The clinical data of a case of rhabdomyolysis complicated by acute kidney injury admitted to Affiliated Huadu Hospital of Southern Medical University on August 30, 2020, were collected, including clinical manifestation, auxiliary examination, and disease outcome. Referring to the previous literature reports of rhabdomyolysis complicated by acute kidney injury, this paper discusses its etiology, monitors and analyzes some indicators such as serum creatinine, blood urea nitrogen, creatine kinase, myoglobin, and 24-hour urine volume during the treatment, and summarizes the clinical diagnosis and treatment ideas of the disease.Results:This case developed an intestinal infection after an unclean diet, which induced rhabdomyolysis and acute kidney injury. Renal pathology after renal biopsy showed that renal biopsy result was consistent with an acute tubulointerstitial injury caused by myoglobin tubular nephropathy. The biochemical indexes such as creatine kinase and myoglobin decreased rapidly after ordinary hemodialysis, but the levels of serum creatinine and blood urea nitrogen did not decrease markedly, and there was continuous oliguria. After switching to hemodialysis filtration and continuous intensive dialysis treatment, the levels of serum creatinine and blood urea nitrogen decreased rapidly, the amount of urine increased gradually, and finally, the renal function recovered.Conclusion:For acute kidney injury caused by rhabdomyolysis, early sufficient blood purification can accelerate the clearance of myoglobin, promote the recovery of the injured kidney, and improve the prognosis of the disease.
