Clinical analysis of 71 patients with Pseudomonas aeruginosa bloodstream infection
10.3760/cma.j.cn341190-20210818-00950
- VernacularTitle:铜绿假单胞菌血流感染71例临床分析
- Author:
Jie LIN
1
;
Mingming LI
;
Peng HUANG
;
Dandan CHAI
;
Qing ZHANG
;
Shengna ZHANG
Author Information
1. 温州医科大学附属第三医院药学部,温州 325200
- Keywords:
Pseudomonas aeruginosa;
Carbapenems;
Infection;
Anti-bacterial agents;
Drug resistance,microbial;
Microbial sensitivity tests;
Risk factors;
Regression analy
- From:
Chinese Journal of Primary Medicine and Pharmacy
2023;30(1):81-86
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical manifestations and related risk factors of patients with Pseudomonas aeruginosa (PAE) bloodstream infection, and to provide references for clinical diagnosis and treatment of PAE bloodstream infection after combining with bacterial resistance condition. Methods:The clinical data and biological data of all patients with PAE bloodstream infection who received treatment in the Third Affiliated Hospital of Wenzhou Medical University from January 2019 to December 2020 were analyzed retrospectively. The independent influential factors of PAE bloodstream infection were analyzed using binary logistic regression. Results:Eighty-three patients had PAE bloodstream infection. Among them, 71 patients were included in the final analysis. Among the 71 patients, 36 patients (50.70%) had carbapenem-resistant Pseudomonas aeruginosa ( CRPA). Univariate analysis showed that the history of hospitalization within 90 days ( χ2 = 3.90, P = 0.048), indwelling catheterization ( χ2 = 5.08, P = 0.024), septic shock ( χ2 = 4.00, P = 0.046), mechanical ventilation ( χ2= 12.35, P < 0.001), deep venous catheter ( χ2 = 4.08, P = 0.043), acute physiology and chronic health evaluation score II ≥ 10 points ( χ2 = 4.06, P = 0.044), and multi-drug resistance ( χ2 = 11.75, P = 0.001) were the suspicious influential factors of CRPA bloodstream infection. Multivariate logistic regression analysis showed that mechanical ventilation was an independent risk factor for CRPA bloodstream infection ( OR = 7.43, 95% CI 1.182-46.674, P = 0.032). Multi-drug resistance was an independent risk factor for CRPA bloodstream infection ( OR = 5.842, 95% CI 1.520-22.450, P = 0.010). Conclusion:Mechanical ventilation and multi-drug resistance are the independent influential factors of CRPA bloodstream infection. Invasive operations such as mechanical ventilation should be avoided in the clinic.
