Research progress of Yersinia pestis phage and their receptors

VernacularTitle:鼠疫噬菌体及其受体研究进展
Author: Rong YANG ¹ ; Peng WANG ; Liyuan SHI ; Yu DU ; Linxuan YANG ; Youhong ZHONG
Author Information

1. 云南省地方病防治所　云南省自然疫源性疾病防控技术重点实验室，大理　671000
Keywords: Plague; Phage; Receptor binding protein
From: Chinese Journal of Endemiology 2023;42(7):588-592
CountryChina
Language:Chinese
Abstract: Yersinia pestis phage is a virus that is parasitic within Yersinia pestis and can specifically lyses Yersinia pestis. The adsorption sites of phage infesting host bacteria are called receptor binding protein (RBP), including extracellular membrane protein, lipopolysaccharide, teichoteic acid, pili, flagella, capsular polysaccharide, etc., of which extracellular membrane protein and lipopolysaccharide are the receptors of Yersinia pestis phage. RBP plays a decisive role in the process of Yersinia pestis phage infecting Yersinia pestis. Therefore, the classification, isolation and application of Yersinia pestis phage are summarized; the research progress in identification and structure of Yersinia pestis phage receptor is analyzed, which is helpful in understanding the cleavage mechanism of Yersinia pestis phage and the interaction mode with Yersinia pestis from the molecular level, and provide more powerful support for in-depth study on Yersinia pestis phage receptor.