Research progress on the ferroptosis role in liver injury induced by inorganic arsenic

VernacularTitle:铁死亡在无机砷致肝损伤中作用的研究进展
Author: Yaermaimaiti DILINAER ¹ ; Fei HUANG ; Guanxin DING ; Shunhua WU
Author Information

1. 新疆医科大学公共卫生学院流行病与卫生统计学教研室，乌鲁木齐　830011
Keywords: Liver fibrosis; Ferroptosis; Inorganic arsenic
From: Chinese Journal of Endemiology 2023;42(4):340-344
CountryChina
Language:Chinese
Abstract: Inorganic arsenic (iAs) is a common carcinogen that exists in the environment. Liver, as the main target organ of arsenic metabolism, long-term exposure to iAs can ultimately lead to carcinogenesis through two stages: liver fibrosis and cirrhosis. Ferroptosis is a type of programmed cell death caused by the accumulation of iron dependent lipid peroxides that affects the normal function of mitochondria. It has been found that ferroptosis occurs during liver fibrosis. Liver fibrosis caused by iAs has been a global health problem for a long time, but so far there is no effective treatment. The discovery of ferroptosis provides a new way to solve this problem. Therefore, this article will review the research progress of the mechanism of liver injury caused by iAs and ferroptosis.