Research progress on the influence of iodine nutritional status on biomarkers of thyroid cancer
10.3760/cma.j.cn231583-20220908-00310
- VernacularTitle:碘营养状况对甲状腺癌生物标志物影响的研究进展
- Author:
Jie LUO
1
;
Xuebin WANG
;
Zhiyong LIU
;
Lijun FAN
Author Information
1. 哈尔滨医科大学中国疾病预防控制中心地方病控制中心碘缺乏病防治研究所 国家卫生健康委病因流行病学重点实验室，哈尔滨 150081
- Keywords:
Iodine nutrition;
Thyroid cancer;
Biomarkers
- From:
Chinese Journal of Endemiology
2023;42(4):335-339
- CountryChina
- Language:Chinese
-
Abstract:
Thyroid cancer is one of the common malignant tumors in the endocrine system, and its incidence is increasing year by year. At present, the main diagnostic methods for thyroid cancer are ultrasound and thyroid puncture cytology. However, due to low sensitivity and/or specificity, it is increasingly difficult to meet the current clinical diagnostic needs. The discovery of biomarkers in thyroid cancer provides important clues for the diagnosis, pathogenesis and prognosis of the disease. As one of the essential trace elements in human body, iodine is closely related to the thyroid gland. Clarifying the relationship between iodine nutritional status and biomarkers of thyroid cancer has important practical significance for the diagnosis, pathogenesis and prognosis of thyroid cancer. Based on the research of systems biology, this article analyzes the influence of iodine nutritional status on biomarkers of thyroid cancer from four aspects of gene, transcription, protein and metabolism,
