Progress in molecular signal pathway of dental fluorosis
10.3760/cma.j.cn231583-20220426-00138
- VernacularTitle:氟斑牙发病分子信号通路研究进展
- Author:
Xinrui WANG
1
;
Guohui BAI
;
Yuan TIAN
Author Information
1. 遵义医科大学口腔医学院，遵义 563000
- Keywords:
Fluorosis, dental;
Signal pathway;
Stress pathway
- From:
Chinese Journal of Endemiology
2023;42(2):159-164
- CountryChina
- Language:Chinese
-
Abstract:
Dental fluorosis is a manifestation of chronic oral fluorosis caused by excessive fluoride intake in childhood. At present, the molecular mechanism of dental fluorosis is still unclear. Ameloblasts are the most sensitive cells to fluoride in tooth tissue. Fluoride affects the proliferation and secretion of ameloblasts through the role of key molecules in the molecular signal pathways, leading to the formation of dental fluorosis. This paper reviews the relationship between the molecular signal pathways [mitogen-activated protein kinase (MAPK), transforming growth factor-β (TGF-β)/Smad, Wnt, Foxo1/Runx2], stress pathways (endoplasmic reticulum stress and oxidative stress) and the occurrence of dental fluorosis in recent years, in order to deeply understand the pathogenesis of dental fluorosis at the molecular level, and provide new ideas for the prevention and treatment of dental fluorosis.
